A.  Positions and Honors.

Positions and Employment

1984-1988                   Postdoctoral Fellow, Dept. of Radiology, University of California at San Francisco

1988-1989                   Adjunct Assistant Professor, Department of Radiology, University of California at San                                           Francisco

1989-1994                   Assistant Professor, Department of Radiology, The University of Chicago, Chicago, IL.

1994- Present             MR Imaging and Spectroscopy Laboratory, The University of Chicago, Chicago, IL.

1996- Present             Associate Professor, Department of Radiology, The University of Chicago, Chicago, IL

Other Experience and Professional Memberships:

1976                Kroll Scholarship, Reed College,

1986                National Research Service Award,

1989                Whitaker Bioengineering Award,

1991                American Cancer Society Junior Faculty Research Award,

1996                Kurt Rossman Award for Excellence in Teaching,

2001 –    Editorial Board, Magnetic Resonance in Medicine

Patents

GS Karczmar, DA Kovar, HA Al-Hallaq, M Zamora, JN River: Fast Spectroscopic Imaging System, Patent No. 6,037,772:  MR data acquisition with high spectral and spatial resolution for improved anatomic and functional images.  Awarded March 14, 2000.

University Committees

1991- present              Institutional Review Board

1996-1999                   Research Advisory Committee, Dept of Radiology

1998-present               Organizer of the contrast media research program

1999-present               Organizer, Department of Radiology Research Seminars

1999                                        Graduate Program in Medical Physics, Curriculum Committee

1999-present               Organizer, Department of Radiology Research Seminars

B.  Selected peer-reviewed publications (in chronological order; from a total of 53 published or in press).

1.      GS Karczmar, DJ Meyerhoff, B. Hubesch, MD Boska, F Valone, DB Tweig, M Wilkinson, GB Matson, and MW Weiner:  Preliminary 31P MR Studies of Human Tumors.  In Magnetic Resonance in Experimental and Clinical Oncology (Ed. J Evelhoc).  Kluwer Academic Press, New York 1989.

2.      GS Karczmar, DJ Meyerhoff, A Speder, F Valone, M Wilkinson, N Shine, MD Boska, and MW Weiner:  Response of Tumors to Therapy Studied by 31P Magnetic Resonance Spectroscopy. Investigative Radiology 24:1020-1023, 1989.

3.      GS Karczmar, DJ Meyerhoff, MD Boska, B Hubesch, J Poole, GB Matson, F Valone, MW Weiner: 31P MRS Study of Response of Superficial Human Tumors to Therapy.  Radiol. 179: 149 -153, 1991.

4.      GS Karczmar, JM Arbeit, BJ Toy, A Speder, and MW Weiner:  Effects of 2-Deoxyglucose and Insulin on Energy Metabolism in Methylcholanthrene Induced Rodent Tumors.  Cancer 52: 71-76, 1991.

5.      GS Karczmar, JN River, M Lewis, et al:  Effects of Hyperoxia on T2* Weighted Magnetic Resonance Images of Tumors.  NMR in Biomedicine 7:3-11 (1994).

6.      GS Karczmar, JN River, Z Goldman, J Li, E Weisenberg, M Zamora, and K Liu:  Magnetic Resonance Imaging of Rodent Tumors Using Radio Frequency Gradient Echoes.  Journal of Magnetic Resonance Imaging; 12(6):881-893, 1994.

7.      GS Karczmar, V Yu Kuperman, JN River, MZ Lewis, and MJ Lipton:  MR Measurement of  Response to Hyperoxia Differentiates Tumors from Normal Tissue and may be sensitive to Oxygen Consumption.  Investigative Radiology 29(2):5161-5163, 1994.

8.      GS Karczmar, River J, and Koretsky AP:  Radiofrequency Magnetic Field Gradient Echoes have Reduced Sensitivity   to Susceptibility Gradients.  Magnetic Resonance Imaging; 13(6):791-797, 1995.

9.      GS Karczmar, JN River, H Oikawa, HA Al-Hallaq, MZ Lewis:  Effects of Carbogen Inhalation on Tumor Oxygenation:  A Comparison of Magnetic Resonance and Oxygen Electrode Measurements.  Journal of Microscopy, 882-883, 1996

10.  DA Kovar, MZ Lewis, J River, MJ Lipton, GS Karczmar:  In Vivo Imaging of Extraction Fraction of Low Molecular   Weight MR Contrast Agents.  Magnetic Resonance in Medicine; 38:259-268, 1997.

11.  H Oikawa, HA Al-Hallaq, MZ Lewis, DA Kovar, GS Karczmar:  Spectroscopic Imaging of the Water Resonance with Short Repetition Time to Investigate Response of Tumors to Hyperoxia. Magnetic Resonance in Medicine; 38:27-32, 1997.

12.  DA Kovar, M Zamora, GS Karczmar:  A New Method for Imaging Perfusion and Contrast Extraction Fraction; Input Functions Derived from Reference Tissues.  Journal of Magnetic Resonance Imaging 8: 1126 - 11341998.

13.  DA Kovar, HA Al-Hallaq, MA Zamora, JN River, GS Karczmar:  Fast Spectroscopic Imaging of  Water and Fat Resonances May Improve the Quality of MR Images.  Academic Radiology 5(4):269-275, 1998.

14.  HA Al-Hallaq, JN River, MZ Lewis, H Oikawa, GS Karczmar.  Correlation of Magnetic Resonance and Oxygen Microelectrode Measurements of Carbogen-Induced Changes in Tumor Oxygenation.  Radiation Oncology, Biology, and Biophysics 41: 151-159, 1998.

15.  GS Karczmar, X Fan, JN River, H Al-Hallaq, M Zamora, C Rinker-Schaeffer, P Losco, K Tarlo, K Kellar.  Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.  Magnetic Resonance in Medicine 43: 633-639 2000

16.  Fan X, River JN, Zamora M, Tarlo K, Kellar K, Rinker-Schaeffer C, and Karczmar GS. Differentiation of non-metastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI, Magn. Reson. Imaging, 45:1046-1055, 2001.

17.  Al-Hallaq HA, Fan X, Zamora M, River JN, Moulder JE, Karczmar GS. Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI, NMR in Biomedicine, 15:28-36, 2002.

18.  Du W, Du YP, Bick U, Fan X, MacEneaney PM, Zamora MA, Medved M, Karczmar GS. High spectral and spatial resolution MR imaging of breast – Preliminary Experience, Radiology 224, 577-585 2002.

19.  GS Karczmar, W Du., M Medved, U Bick, P MacEneaney,   Du Y, X Fan, M Zamora, M Lipton.  Spectrally inhomogeneous effects of contrast agents in breast lesions detected by high spectral and spatial resolution MRI.  Academic Radiology 9: S352 – S354, 2002.

20.  GS Karczmar, X Fan, HA Al-Hallaq, JN River, K Tarlo, K Kellar, M Zamora, C Rinker-Schaeffer, and MJ Lipton.  Functional and anatomic imaging of tumor vasculature:  High-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.  Academic Radiology 9: S115 – S118, 2002.

21.  Fan, X., Du, W., MacEneaney, P., Zamora, M., and Karczmar, G.S.  Structure of the water resonance in small voxels in rat brain detected with high spectral and spatial resolution MRI.   Journal of Magnetic Resonance Imaging, 16: 547 – 552, 2002.

22.  Fan, X., River JN, Zamora M, Al-Hallaq HA, Karczmar GS. Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements. Int J Radiat Oncol Biol Phys. 15: 1202-1209, 2002.

23.  Du, W., Karczmar GS, Pan X.  Effects of constant frequency noise in magnetic resonance imaging with nonuniform k-space sampling. Med Phys. 29: 1832-8, 2002.

C. Research Support

Ongoing Research Support

1 RO1 CA78803 (Karczmar)                                                              09/01/99 - 08/31/03

NCI     

Fast Spectroscopic MR Imaging of Breast Cancer

The goal of this project is to develop and evaluate a new Magnetic Resonance (MR) imaging method that will greatly improve images of the breast.

Role: PI

DAMD-17-99-1-9121 (Karczmar)                                                       9/15/99-10/14/03

USAMRMC                 

DirectImproved MR Images of Breast Lesions with Fast Spectroscopic Imaging

The goal of this project is to develop methods to obtain MR images with high spectral and special resolution and test them by scanning women who are at high risk of breast cancer.

Role: PI

RSG-97-112-04-CCE (Karczmar)                                                     07/01/97-6/30/04

ACS    

The Use of MR to Study Tumor Response to Hyperoxia

The goal of this project is to test the hypothesis that decreases in line width of MR water signals in tumors caused by TOX’s correlate with the effect of TOX's on radiosensitivity.

Role: PI

5 P30 CA14599-29 (Vogelzang)                                                         02/01/77-06/31/07

CRC   

MRIS Core Facility

The goal of this project is to develop of MRI methods, which guide design and application of anti-angiogenesis therapies.

Role: Investigator

1 R01 CA89452-01 (Giger)                                                                 04/24/01-03/31/06

NIH                 

Computer-Aided Diagnosis in Breast Imaging

The long-term goal of this research is to develop and evaluate computer-aided diagnosis and prognosis methods for multi-modality imaging of the breast.

Role: Co-Investigator

DAMD17-02-1-0033 (Karczmar)                                                        12/24/01 – 1/23/05

USAMRAA                  

Angiogenesis and Invasiveness in Prostate Cancer Detected with High Spectral & spatial Resolution MRI

The goal of this project is to develop new magnetic resonance imaging (MRI) methods to improve early and accurate detection of prostate cancer, and guide treatment of the cancer.  This new, more specific and sensitive MRI methods would have a significant impact on the clinical management of prostate cancer.

Role: PI

1 R21 CA089408-02 (Karczmar)                                                       12/01/01 - 11/30/03

NCI     

High Spectral & Spatial Resolution MRI of Rodent Tumors

The proposed research tests the hypothesis that contrast enhanced HiSS MRI can distinguish metastatic tumors from non-metastatic tumors based on measures of image texture and edge delineation. We will develop methods for acquiring and processing HiSS datasets to maximize contrast, edge delineation and signal-to-noise ratio.

Role: PI

DAMD17-02-1-0034 (Pelizzari)                                                          01/07/02 - 01/06/05

U.S. Army Medical Research

Image Guidance and Assessment of Radiation Induced Gene Therapy

This work involves the use of EPR oxygen imaging and MRI perfusion imaging to localize maximum effect from anticancer therapy. The therapy involves the simultaneous administration of radiation and intratumoral injection of an AD-EGR-TNF adenoviral construct with a radiation inducible EGR promoter to stimulate transcription of TNF. The adenoviral construct will be injected initially along a single needle track. Imaging will be used to localize the effect around the track. Subsequent effort will analyze attempts at homogeneous injection and, from the results of one set of injections, suggest where subsequent injections should be placed to optimize effect.

Role: Co-Investigator

Completed Research Support

1 R01 CA75476 (Karczmar)                                                               09/01/99 - 06/30/03

NCI                   

Effects of Radiosensitizers Measured by MRI

The goal of this project is to test the hypothesis that decreases in line width of MR water signals in tumors caused by TOX’s correlate with changes in pO2 measured by 19F MRI and oxygen microelectrodes.

Role: PI

21508 (Kindler)                                                                                   12/15/00-4/15/03

MARF 

A Phase II  of the VEGF Receptor Inhibitor SU5416 in Patients with Malignant Mesothelioma: Biologic Markers of Angiogensis.

This Phase II Trial assesses the efficay of the angiogensis inhibitor SU5416 in mesothelioma patients and evaluates surrogate endpoints of target inhibition.

Role: Investigator

5 P30 CA14599-27 (Vogelzang)                                                         08/01/00 - 07/31/01    

NIH     

MRIS Core Facility

This project is to promote the development of MRI methods, which guide design, and application of anti-angiogenesis therapies.

Role: Investigator