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Bill O'Brien-Penney is actively involved in developing and evaluating
reconstruction methods for single photon emission computed tomography (SPECT).
Of particular interest are methods to reduce the effects of scatter, distance
dependent collimator blurring, and attenuation. He also serves as Clinical
Physicist for the Nuclear Medicine Section of the Radiology Department. In that
role, he oversees gamma camera quality control, aids in equipment selection, and
performs acceptance testing.
EDUCATION
Ph.D. in Biomedical Engineering, Worcester Polytechnic Institute (WPI), 1979.
HONORS
Eta Kappa Nu (Electrical Engineering Honor Society)
CERTIFICATION
The American Board of Radiology in Medical Nuclear Physics
PROFESSIONAL EXPERIENCE
Assistant Professor, Biomedical Engineering Dept., WPI, 1979 to 1983.
Assistant Professor, Nuclear Medicine Dept., U. Mass. Medical Center, 1985 to 1991
Associate Professor, Nuclear Medicine Dept., U. Mass. Medical Center, 1991 to 1994
Associate Professor, Radiology Dept., U. of Chicago, 1994 to present
RESEARCH INTERESTS
Reconstruction methods for single photon emission computed tomography (SPECT)
Scatter correction methods for SPECT and positron emission tomography (PET)
Attenuation correction methods for SPECT and PET
SELECTED PUBLICATIONS
[1] Penney BC, Peura RA, Narducci LM, Anderson FA Jr and Wheeler HB: The sampling field associated with tetrapolar impedance plethysmography, Proc N Engl Bioeng Conf 2:149-160, Pergamon Press, Elmsford, NJ 1974.
[2] Penney BC: Theory and cardiac applications of electrical impedance measurements, CRC Critical Reviews in Biomedical Engineering 13:227-281, 1986.
[3] Penney BC, King MA, Schwinger RB, Baker SP, Stritzke P and Doherty PW: Constrained least squares restoration of nuclear medicine images: selecting the coarseness function, Med Phys 14:849-858, 1987.
[4] Penney BC, King MA, Schwinger RB, Baker SP and Doherty PW: Modifying constrained least squares restoration for application to SPECT projection images, Med Phys 15:334-342, 1988.
[5] Penney BC, Glick SJ and King MA: Relative importance of the error sources in Wiener restoration of scintigrams. IEEE Med Imag 9:60-70, 1990.
[6] Penney BC, King MA and Knesaurek K: A projector, back-projector, pair which accounts for the two-dimensional depth and distance dependent blurring in SPECT. IEEE Nucl Sci 37:681-686, 1990.
[7] Penney BC, King MA and Glick SJ: Restoration of combined conjugate images in SPECT: Comparison of a new Wiener filter and the image-dependent Metz filter. IEEE Nucl Sci 37:707-712, 1990.
[8] King MA, Coleman M, Penney BC, Glick SJ. Activity quantitation in SPECT: a study of prereconstruction Metz filtering and use of the scatter degradation factor. Med Phys. 1991 18(2):184-9, 1991.
[9] Long DT, King MA, Penney BC. 2D vs. 3D edge detection as a basis for volume quantitation in SPECT. Prog Clin Biol Res. 363:457-71, 1991
[10] King MA, Glick SJ and Penney BC: Activity quantitation in SPECT: a comparison of three attenuation correction methods in combination with pre-reconstruction restoration filtering. IEEE Nucl Sci 38:755-760, 1991.
[11] Wheeler HB, Penney BC, Anderson FA Jr and Peura RA: Impedance plethysmography: Theoretical and experimental basis. In: Non-invasive Diagnostic Techniques in Vascular Disease, 1st, 2nd, 3rd, and 4th eds, Bernstein EF (ed), CV Mosby Co, St. Louis, 1978, 1982, 1985, 1993.
[12] Glick SJ, Penney BC, King MA and Byrne CL: "Non-iterative compensation for the distance-dependent detector response and photon attenuation in SPECT imaging," IEEE Med Imag 13:363-374, 1994.
[13] Glick SJ, Penney BC, King MA and Byrne CL: "Reducing the computational load of iterative SPECT reconstruction methods by pre-processing the projection data to compensate for non-stationary resolution and attenuation," Proc. SPIE 2167:226-234, 1994.
[14] Penney BC and Morgan HT: "Transmission imaging on a dual head SPECT system with non-uniform sources," J Nucl Med 36:170P, 1995.
[15] Pan, T-S, King MA, Penney BC, Rajeevan N, Luo D-S and Case JA: "Reduction of truncation artifacts in fan beam transmission by using parallel beam emission data," IEEE Trans Nuc Sci 42:1310-1320, 1995.
[16] King MA, Luo D, Dahlberg ST, Villegas BJ, Penney BC and Morgan HT: "Transmission imaging of large attenuators using slant hole collimators on a three-headed SPECT system, Med. Phys., 23:263-72, 1996.
[17] Liu H, Fajardo LL and Penny [sic] BC: "Signal-to-Noise ratio and detective Quantum efficiency analysis of optically coupled CCD mammography imaging systems", Academic Radiology, 3: 799-805, 1996.
[18] Ryan J, Penney B, Al-Hallaq H and Weissman I: Rapid acquisition sequence (RAS) imaging with dual or triple head gamma cameras reduces bladder filling artefacts, Eur J Nucl Med, 25:910, 1998.
[19] Kao C-M, Penney BC, Pan X, Bidani N, and Weissman IA: "Reducing urinary bladder artifact in SPECT reconstructions using low noise, analytic correction for uniform attenuation," J Nucl Med, 40: 303P, 1999.
[20] Licho R, Glick SJ, Xia W, Pan TS, Penney BC, King MA. Attenuation compensation in 99mTc SPECT brain imaging: a comparison of the use of attenuation maps derived from transmission versus emission data in normal scans. J Nucl Med. 1999 Mar; 40(3):456-63.
[21] Penney, BC., Kao, C.-M., Pan, X., and Bidani, N.: Dual isotope (In-111/Tc-99m) SPECT: noise reduction with an analytic attenuation correction method, 2000 IEEE Nuclear Science Symposium Conference Record, Lyon, France, pp. 13-20 to 13-24, 2001.
[22] C.-M. Kao, X. Pan, and B.C. Penney, “Toward Optimal Reduction of Noise and Errors in Non-Iterative Reconstruction Methods for 3D SPECT,” Conference Record of the 2000 IEEE Nuclear Science Symposium and Medical Imaging Conference, 2, pp. 15_132-15_136, 2001.
[23] Penney, B. C., Kao, C.-M., Pan, X., and Bidani, N.: Dual isotope (In-111/Tc-99m) SPECT: noise and artifact reduction with an analytic attenuation correction method, Conference Record of the 2000 IEEE Nucl Sci Symp & Med Imag Conf, 2, pp. 13_20-13_24, 2001
[24] Penney BC, Kao C-M, and Pan X: Attenuation correction of Tc-99m/In-111 SPECT studies: Effect of relative isotopic concentration, J Nuc Med, 42:193P, 2001.
[25] Feng J, Penney BC, and Pan X: Convolution estimation of spill-down and scatter in dual isotope (Tc-99m/In-111) SPECT, Proc. SPIE, 4682:73-81,2002..
[26] Penney BC, Feng J and Pan X: Comparison of convolution and triple-energy-window spill-down and scatter correction in Tc-99m/In-111 SPECT, J Nucl Med, 43:907 Suppl. S, 2002.
[27] Penney, BC., Kao, C.-M., Pan, X., and Bidani, N.: “Dual-isotope (In-111/Tc-99m) SPECT: noise and artifact reduction with an analytic attenuation correction method,” IEEE Trans. Nucl. Sci., 49:733-739, 2002.
[28] Naclerio RM, Baroody FM, Bidani N, De Tineo M and Penney BC: A comparison of nasal clearance after treatment of perennial allergic rhinitis with budesonide and mometasone, Otolaryngol Head Neck Surg, 128:220-227, 2003.
[29] Penney BC, Kao C-M, Pan X and Chen HT: PET/CT: Testing for effects of attenuation outside the CT field-of-view, IEEE Medical Imaging Conference, Rome, Italy, paper M10-316, 2004
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